Methyl iodide → HCID 60164183, compound

HRID 2167085Notes

Reaction equation

HRID 2167085 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][CH2:5][CH2:4][CH:3]1[CH2:8][N:9]([CH:16]1[CH2:24][C:23]2[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=2)[CH2:17]1)[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1.[CH3:25][I:26]>ClCCCl>[I-:26].[CH3:1][N+:2]1([CH3:25])[CH2:7][CH2:6][CH2:5][CH2:4][CH:3]1[CH2:8][N:9]([CH:16]1[CH2:24][C:23]2[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=2)[CH2:17]1)[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 9798809HCID 9798809, compound

Product 1

HCID 60164183HCID 60164183, compound

Reagents, catalysts & solvents 1

HCID 111,2-DichloroethaneSolvent

Procedure

To a stirred solution of compound 17 (0.1 g, 0.31 mmol) in DCE (5 mL) was added methyl iodide (0.058 mL, 0.94 mmol) and the resulting mixture was stirred at rt for 16 hours. The reaction mixture was concentrated under reduced pressure and the crude material was purified by crystallization from methanol-ether to provide 1,1-dimethyl-2-[((indan-2-yl)(phenyl)amino)methyl]piperidinium iodide.

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. customthe crude material was purified by crystallization from methanol-ether

Sources & evidence

ORD record
ord-8658b910c3244da1bdd0259c01838ce7
Source dataset
uspto-grants-2015_06
Patent number
US09044482B2

Reaction notes

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