反应详情

温度

80 °C

2-Chloro-6-methoxy-4-(trifluoromethyl)benzaldehyde (224 mg, 0.94 mmol), (4-(methoxycarbonyl)phenyl)boronic acid (219 mg, 1.22 mmol), S-PHOS (115 mg, 0.28 mmol), Pd(Oac)2 (32 mg, 0.14 mmol) and K3PO4 (597 mg, 2.81 mmol) were dissolved in wet PhMe (8 mL) and the resulting mixture was heated to 80° C. After 16 h the resulting mixture was diluted with water and extracted with EtOAc. The combined organic extracts were dried (Na2SO4), concentrated, and purified via column chromatography to yield the title compound.

1. extractionextracted with EtOAc
2. dry with materialThe combined organic extracts were dried (Na2SO4)
3. concentrationconcentrated
4. custompurified via column chromatography