HCID 86674214, compound → HCID 71060109, compound

HRID 2167152Notes

Reaction equation

HRID 2167152 reaction equation
[CH:1]([C:3]1[C:8]([C:9]([CH3:11])=[CH2:10])=[CH:7][C:6]([C:12]([F:15])([F:14])[F:13])=[CH:5][C:4]=1[C:16]1[CH:21]=[CH:20][C:19]([C:22]([O:24][CH3:25])=[O:23])=[CH:18][CH:17]=1)=[O:2]>CO>[OH:2][CH2:1][C:3]1[C:8]([CH:9]([CH3:11])[CH3:10])=[CH:7][C:6]([C:12]([F:15])([F:14])[F:13])=[CH:5][C:4]=1[C:16]1[CH:17]=[CH:18][C:19]([C:22]([O:24][CH3:25])=[O:23])=[CH:20][CH:21]=1

Participants

3

Reactant 1

HCID 86674214HCID 86674214, compound

Product 1

HCID 71060109HCID 71060109, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of methyl 2′-formyl-3′-(prop-1-en-2-yl)-5′-(trifluoromethyl)-[1,1′-biphenyl]-4-carboxylate (122 mg, 0.35 mmol) in MeOH (10 mL) was hydrogenated using H-Cube (10 Bar H2) at 40° C. at a flow rate of 1 mL/min. The resulting solution was concentrated to yield the title compound, which was used in the next step without further purification.

Workup

  1. customat 40° C.
  2. concentrationThe resulting solution was concentrated

Sources & evidence

ORD record
ord-a7dd574d98224d69b6903de421ace3b5
Source dataset
uspto-grants-2015_06
Patent number
US09045389B2

Reaction notes

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