HuagongsheHuagongshe Chemistry Print Report · For research reference only
Amyl isothiocyanate → O-((2E,6E,10E)-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraen-1-yl) butylcarbamothioate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Amyl isothiocyanate | HCID 69415 | — |
| Reactant | Geranylgeraniol | HCID 5281365 | — |
| Reactant | O-((2E,6E,10E)-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraen-1-yl) pyridin-3-ylcarbamothioate | HCID 86701128 | — |
| Product | O-((2E,6E,10E)-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraen-1-yl) butylcarbamothioate | HCID 86701130 | 60% |
Reaction Steps
Similar to the preparation of 38a, the reaction of alcohol 1 with pentyl isothiocyanate afforded the desired compound 10e in 60% yield (135 mg) as a viscous oil. Column (EtOAc/Hexane); TLC Rf: 0.70 (10% EtOAc/hexanes); LCMS: MS (m/z): 406.1 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09045403B2 |
| Source dataset | uspto-grants-2015_06 |
| ORD ID | ord-7445d9dbd2d943a6af136cf962a8430c |
| Source note | uspto-grants-2015_06 |