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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2167204Generated: October 28, 2026

Memantine → (2E,6E,10E)-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraen-1-yl (3,5-dimethyladamantan-1-yl)carbamate

https://huagongshe.com/reaction/2167204

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMemantineHCID 4054—
Reactant1,1'-CarbonyldiimidazoleHCID 68263—
ReactantGeranylgeraniolHCID 5281365—
Reactant3,7,11,15-Tetramethylhexadeca-2,6,10,14-tetraen-1-yl 4-methylpiperazine-1-carboxylateHCID 78164056—
Product(2E,6E,10E)-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraen-1-yl (3,5-dimethyladamantan-1-yl)carbamateHCID 86701131—

Reaction Steps

Similar to the preparation of 40a, the reaction of alcohol 1 with memantine and CDI afforded the desired compound 41 as a viscous oil. Column (DCM/MeOH); TLC Rf: 0.70 (10% EtOAc/Hexanes).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09045403B2
Source datasetuspto-grants-2015_06
ORD IDord-75114d30f11e4d4fb08e4bfc9a95b972
Source noteuspto-grants-2015_06