HRID2167204

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID4054

Memantine

C12H21N

HCID68263

1,1'-Carbonylbis(1H-imidazole)

C7H6N4O

结构：CC(C)=CCC/C(C)=C/CC/C(C)=C/CC/C(C)=C/CO

HCID5281365

Geranylgeraniol

C20H34O

结构：CC(C)=CCCC(C)=CCCC(C)=CCCC(C)=CCOC(=O)N1CCN(C)CC1

HCID78164056

未命名化合物

PRODUCTS

生成物

结构：CC(C)=CCC/C(C)=C/CC/C(C)=C/CC/C(C)=C/COC(=O)NC12CC3CC(C)(CC(C)(C3)C1)C2

HCID86701131

未命名化合物

PROCEDURE

实验过程

Similar to the preparation of 40a, the reaction of alcohol 1 with memantine and CDI afforded the desired compound 41 as a viscous oil. Column (DCM/MeOH); TLC Rf: 0.70 (10% EtOAc/Hexanes).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-75114d30f11e4d4fb08e4bfc9a95b972
来源数据集: uspto-grants-2015_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09045403B2
来源说明: uspto-grants-2015_06

反应 SMILES

CN1[CH2:7][CH2:6][N:5]([C:8]([O:10][CH2:11][CH:12]=[C:13]([CH3:30])[CH2:14][CH2:15][CH:16]=[C:17]([CH3:29])[CH2:18][CH2:19][CH:20]=[C:21]([CH3:28])[CH2:22][CH2:23][CH:24]=[C:25]([CH3:27])[CH3:26])=[O:9])CC1.C(C/C(/C)=C/CC/C(/C)=C/CO)/C=C(/CCC=C(C)C)\C.[CH3:52][C:53]12[CH2:62]C3(N)[CH2:61][CH:55]([CH2:56][C:57](C)([CH2:59]3)[CH2:58]1)[CH2:54]2.C1N=CN(C(N2C=NC=C2)=O)C=1>>[CH3:52][C:53]12[CH2:58][CH:57]3[CH2:56][C:55]([CH3:61])([CH2:7][C:6]([NH:5][C:8](=[O:9])[O:10][CH2:11]/[CH:12]=[C:13](\[CH3:30])/[CH2:14][CH2:15]/[CH:16]=[C:17](\[CH3:29])/[CH2:18][CH2:19]/[CH:20]=[C:21](\[CH3:28])/[CH2:22][CH2:23][CH:24]=[C:25]([CH3:26])[CH3:27])([CH2:59]3)[CH2:62]1)[CH2:54]2