反应详情

Compound 29 was synthesized from 5-morpholinyl-2-aminobenzamide (13) (1.6 g, 7.3 mmol) and 1-naphthaldehyde (14) (1.1 g, 7.3 mmol): yield 1.7 g (64%); yellow crystals; mp 291 to 293° C.; 1H NMR (DMSO-d6) δ 3.22 (4H, t, J=4.7 Hz, CH2NCH2), 3.77 (4H, t, J=4.7 Hz, CH2OCH2), 7.51-7.66 (6H, m, 6×ArH), 7.73-7.76 (1H, m, 1×ArH), 8.00-8.11 (3H, m, 3×ArH), 12.48 (1H, br s, NH) ppm; MS (ESI) m/z 357; Anal. (C22H19N3O2): C, H, N.