Ethyl 3-(2,3-difluoro-4-hydroxyphenyl)propanoate → 3-(4-{[1-(4-Chlorophenyl)-3-(trifluoromethyl)-1H-pyrrol-2-yl]methoxy}-2,3-difluorophenyl)propan-1-ol
반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH:12]=[CH:11][C:10]([C:13]([F:16])([F:15])[F:14])=[C:9]2[CH2:17][OH:18])=[CH:4][CH:3]=1.[F:19][C:20]1[C:25]([F:26])=[C:24](O)[CH:23]=[CH:22][C:21]=1[CH2:28][CH2:29][C:30](OCC)=[O:31]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[CH:12]=[CH:11][C:10]([C:13]([F:14])([F:15])[F:16])=[C:9]2[CH2:17][O:18][C:24]2[CH:23]=[CH:22][C:21]([CH2:28][CH2:29][CH2:30][OH:31])=[C:20]([F:19])[C:25]=2[F:26])=[CH:6][CH:7]=1참가 물질
3
실험 절차
The title compound was prepared by reacting the product prepared in Step D of Example 1 and ethyl 3-(2,3-difluoro-4-hydroxyphenyl)propanoate according to the procedure described in Example 1, Step E, and then according to Example 2.
출처 및 근거
- ORD 기록
- ord-26df5c89c5294822b4bbeaaf88f47faf
- 출처 데이터셋
- uspto-grants-2015_06
- 특허 번호
- US09045454B2
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