Hydrochloric Acid → HCID 18769864, compound

HRID 2167409Notes

Reaction equation

HRID 2167409 reaction equation
[CH2:1]([N:3]([CH2:11][CH2:12][CH:13]([CH3:15])[CH3:14])C(=O)OC(C)(C)C)[CH3:2].[ClH:16]>CO>[ClH:16].[CH2:1]([NH:3][CH2:11][CH2:12][CH:13]([CH3:15])[CH3:14])[CH3:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 117613432HCID 117613432, compound

Product 1

HCID 18769864HCID 18769864, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of tert-butyl ethyl(iso-pentyl)carbamate (490 mg, 2.28 mmol, 1.00 equiv) in methanol (3 mL) and 12N hydrochloric acid (2 mL) was stirred at room temperature for 2 h. The resulting mixture was concentrated under vacuum to give 0.55 g of crude N-ethyl-3-methylbutan-1-amine hydrochloride as a white solid. 1H-NMR (300 MHz, D2O): δ 3.01-2.91 (m, 4H), 1.60-1.14 (m, 3H), 1.19 (t, J=7.5 Hz, 3H), 0.82 (d, J=7.8 Hz, 6H) ppm.

Workup

  1. concentrationThe resulting mixture was concentrated under vacuum

Sources & evidence

ORD record
ord-0817e1fa56584a6393356fad27a2c019
Source dataset
uspto-grants-2015_06
Patent number
US09045455B2

Reaction notes

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