Thionyl Chloride → 3-(Chloromethyl)-8-methyl-2-o-tolylquinoline

HRID 216743노트

반응식

HRID 216743 반응식
[CH3:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[N:10]=[C:9]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[CH3:18])[C:8]([CH2:19]O)=[CH:7]2.O=S(Cl)[Cl:23]>C(Cl)(Cl)Cl>[Cl:23][CH2:19][C:8]1[C:9]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[CH3:18])=[N:10][C:11]2[C:6]([CH:7]=1)=[CH:5][CH:4]=[CH:3][C:2]=2[CH3:1]

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 57707986(8-Methyl-2-o-tolylquinolin-3-yl)methanol

생성물 1

HCID 575561733-(Chloromethyl)-8-methyl-2-o-tolylquinoline

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

Prepared according to Procedure C using (8-methyl-2-o-tolylquinolin-3-yl)-methanol (670 mg, 2.5 mmol) and SOCl2 (0.91 mL, 5 eq) in CHCl3 (10 mL). After isolation, the resultant oil was carried on crude without purification for the next step.

후처리

  1. customPrepared
  2. customAfter isolation, the resultant oil was carried on crude without purification for the next step

출처 및 근거

ORD 기록
ord-d6276ba642af47418dcbba960a738f46
출처 데이터셋
uspto-grants-2012_06
특허 번호
US08193199B2

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