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Thionyl Chloride → 3-(Chloromethyl)-8-methyl-2-o-tolylquinoline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Thionyl Chloride | HCID 24386 | — |
| 反応物 | (8-Methyl-2-o-tolylquinolin-3-yl)methanol | HCID 57707986 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 生成物 | 3-(Chloromethyl)-8-methyl-2-o-tolylquinoline | HCID 57556173 | — |
反応手順
Prepared according to Procedure C using (8-methyl-2-o-tolylquinolin-3-yl)-methanol (670 mg, 2.5 mmol) and SOCl2 (0.91 mL, 5 eq) in CHCl3 (10 mL). After isolation, the resultant oil was carried on crude without purification for the next step.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08193199B2 |
| 出典データセット | uspto-grants-2012_06 |
| ORD ID | ord-d6276ba642af47418dcbba960a738f46 |
| 出典メモ | uspto-grants-2012_06 |