1-(3-Bromopropoxy)-4-fluorobenzene → HCID 11548210, compound

HRID 2167591Notes

Reaction equation

HRID 2167591 reaction equation
[N:1]12[CH2:8][CH2:7][C:4]([C:9]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)[OH:10])([CH2:5][CH2:6]1)[CH2:3][CH2:2]2.[F:23][C:24]1[CH:29]=[CH:28][C:27]([O:30][CH2:31][CH2:32][CH2:33][Br:34])=[CH:26][CH:25]=1>CC#N>[Br-:34].[F:23][C:24]1[CH:29]=[CH:28][C:27]([O:30][CH2:31][CH2:32][CH2:33][N+:1]23[CH2:6][CH2:5][C:4]([C:9]([OH:10])([C:17]4[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=4)[C:11]4[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=4)([CH2:3][CH2:2]2)[CH2:7][CH2:8]3)=[CH:26][CH:25]=1

Participants

4

Reactant 2

HCID 2600041-(3-Bromopropoxy)-4-fluorobenzeneHCID 239923851-Azabicyclo[2.2.2]oct-4-yl(diphenyl)methanol

Product 1

HCID 11548210HCID 11548210, compoundYield 43.7%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Following the general procedure outlined in Example 3, 1-azabicyclo[2.2.2]oct-4-yl(diphenyl)methanol (0.0182 g, 0.0621 mmol) and 3-bromopropyl 4-fluorophenyl ether (0.0173 g, 0.0742 mmol) in 2 CH3CN/3 CHCl3 (4.0 mL) were reacted to give the desired product (0.0143 g, 43.7%). EI-MS m/z 446 (M+) Rt (1.96 min).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-44e37e17971348279fc15a1443571dbc
Source dataset
uspto-grants-2015_06
Patent number
US09045469B2

Reaction notes

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