HCID 90426456, compound → HCID 90427279, compound

HRID 2167682Notes

Reaction equation

HRID 2167682 reaction equation
[CH3:1][N:2]1[CH:10]=[C:9]2[C:4]([C:5]([C:12]#[N:13])=[C:6]([CH3:11])[CH:7]=[CH:8]2)=[N:3]1>CO.N.[Ni]>[CH3:1][N:2]1[CH:10]=[C:9]2[C:4]([C:5]([CH2:12][NH2:13])=[C:6]([CH3:11])[CH:7]=[CH:8]2)=[N:3]1

Participants

5

Reactant 1

HCID 90426456HCID 90426456, compound

Product 1

HCID 90427279HCID 90427279, compound

Reagents, catalysts & solvents 3

HCID 935NickelCatalystHCID 222AmmoniaSolventHCID 887MethanolSolvent

Procedure

To a solution of 2,6-dimethyl-2H-indazole-7-carbonitrile (1 equiv.) in methanol and aq. ammonia solution (9:1), catalytic amount of Raney Nickel was added. Reaction mass was stirred at room temperature under hydrogen pressure (balloon pressure) for 2-5 h. On completion of reaction, it was filtered through celite bed and filtrate was concentrated under reduce pressure to afford the title compound (quant. yield).

Workup

  1. customReaction mass
  2. customOn completion of reaction, it
  3. filtrationwas filtered through celite bed and filtrate
  4. concentrationwas concentrated

Sources & evidence

ORD record
ord-4d31ed78d32a4f1280d6ebe2cc83c47c
Source dataset
uspto-grants-2015_06
Patent number
US09045477B2

Reaction notes

Loading…