HCID 15483103, compound → 1-(Pyrazolo[1,5-a]pyridin-7-yl)methanamine

HRID 2167685Notes

Reaction equation

HRID 2167685 reaction equation
[N:1]1[N:5]2[C:6]([C:10]#[N:11])=[CH:7][CH:8]=[CH:9][C:4]2=[CH:3][CH:2]=1>CO.N.[Ni]>[N:1]1[N:5]2[C:6]([CH2:10][NH2:11])=[CH:7][CH:8]=[CH:9][C:4]2=[CH:3][CH:2]=1

Participants

5

Reactant 1

HCID 15483103HCID 15483103, compound

Product 1

HCID 513585261-(Pyrazolo[1,5-a]pyridin-7-yl)methanamine

Reagents, catalysts & solvents 3

HCID 935NickelCatalystHCID 222AmmoniaSolventHCID 887MethanolSolvent

Procedure

To a solution of pyrazolo[1,5-a]pyridine-7-carbonitrile (1 equiv.) in methanol and aq. ammonia solution (9:1), catalytic amount of Raney Nickel was added. Reaction mass was stirred at room temperature under hydrogen pressure (balloon pressure) for 2-5 h. On completion of reaction, it was filtered through celite bed and filtrate was concentrated under reduce pressure to afford the title compound (quant. yield).

Workup

  1. customReaction mass
  2. customOn completion of reaction, it
  3. filtrationwas filtered through celite bed and filtrate
  4. concentrationwas concentrated

Sources & evidence

ORD record
ord-03430da6f79d404189890272c1555e77
Source dataset
uspto-grants-2015_06
Patent number
US09045477B2

Reaction notes

Loading…