4-Methylbenzamide → HCID 12437398, compound

HRID 2167692Notes

Reaction equation

HRID 2167692 reaction equation
[CH3:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([NH2:8])=[O:7])=[CH:4][CH:3]=1.Cl[C:12]([S:14]Cl)=[O:13]>C1(C)C=CC=CC=1>[CH3:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]2[O:7][C:12](=[O:13])[S:14][N:8]=2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 692744-MethylbenzamideHCID 75990(Chlorothio)formyl chloride

Product 1

HCID 12437398HCID 12437398, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Conditions

Temperature
120 °C

Procedure

To a toluene (60 mL) suspension of 4-methylbenzamide (20 g), chlorocarbonylsulfenyl chloride (15 mL) was added, and the resultant was stirred at 120° C. for 3 hours. The reaction solution was concentrated under reduced pressure. The obtained solid was washed with hexane to obtain the title compound (24 g) as a colorless solid.

Workup

  1. additionwas added
  2. concentrationThe reaction solution was concentrated under reduced pressure
  3. washThe obtained solid was washed with hexane

Sources & evidence

ORD record
ord-5ed1af5e37e440bf846c1d5f99b4c804
Source dataset
uspto-grants-2015_06
Patent number
US09045466B2

Reaction notes

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