Bromine → HCID 90185062, compound

HRID 2167697Notes

Reaction equation

HRID 2167697 reaction equation
[F:1][C:2]([F:15])([F:14])[C:3]1[CH:8]=[CH:7][C:6]([C:9](=[O:13])[C:10](=[O:12])[CH3:11])=[CH:5][CH:4]=1.[Br:16]Br.S([O-])([O-])(=O)=S.[Na+].[Na+]>C(Cl)(Cl)Cl>[Br:16][CH2:11][C:10](=[O:12])[C:9]([C:6]1[CH:5]=[CH:4][C:3]([C:2]([F:14])([F:15])[F:1])=[CH:8][CH:7]=1)=[O:13]

Participants

5

Reactant 3

HCID 24408BromineHCID 24477Sodium ThiosulfateHCID 27776811-[4-(trifluoromethyl)phenyl]propane-1,2-dione

Product 1

HCID 90185062HCID 90185062, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Conditions

Temperature
70 °C

Procedure

To a chloroform (6.0 mL) solution of 1-[4-(trifluoromethyl)phenyl]propane-1,2-dione (0.65 g), bromine (0.62 mL) was added, and the resultant was stirred at 70° C. for 6 hours. After standing to cool to room temperature, a 10% aqueous sodium thiosulfate solution was added thereto, followed by extraction with chloroform. An organic layer was separated using a phase separator, and the solvent was distilled off under reduced pressure to obtain the title compound (1.1 g) as a yellow oil.

Workup

  1. temperatureto cool to room temperature
  2. extractionfollowed by extraction with chloroform
  3. customAn organic layer was separated
  4. distillationthe solvent was distilled off under reduced pressure

Sources & evidence

ORD record
ord-ddd1b302b77b4f358ebda7331f22eccf
Source dataset
uspto-grants-2015_06
Patent number
US09045466B2

Reaction notes

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