Hydrochloric Acid → HCID 11845779, compound

HRID 2167772Notes

Reaction equation

HRID 2167772 reaction equation
[N:1]1[C:2]([C:10]([O:12][CH2:13][CH3:14])=[O:11])=[CH:3][N:4]2[CH:9]=[CH:8][N:7]=[CH:6][C:5]=12.[ClH:15]>CCO.[Pd]>[ClH:15].[N:1]1[C:2]([C:10]([O:12][CH2:13][CH3:14])=[O:11])=[CH:3][N:4]2[CH2:9][CH2:8][NH:7][CH2:6][C:5]=12

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 11845418ethyl imidazo[1,2-a]pyrazine-2-carboxylate

Product 1

HCID 11845779HCID 11845779, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

10% Pd/C (40 mg) was added to a stirred solution of Ethyl imidazo[1,2-a]pyrazine-2-carboxylate (410 mg, 2.15 mmol) and conc.HCl (0.5 mL) in EtOH (9.5 mL) under inert atmosphere. The reaction mixture was stirred continuously under hydrogen atmosphere for 16 h. The reaction mixture was filtered over a celite bed-and the filtrate was concentrated under reduced pressure to afford a solid product, which was washed with diethyl ether and dried to afford 400 mg of the title compound as a yellow solid.

Workup

  1. filtrationThe reaction mixture was filtered over a celite bed-
  2. concentrationthe filtrate was concentrated under reduced pressure
  3. customto afford a solid product, which
  4. washwas washed with diethyl ether
  5. customdried

Sources & evidence

ORD record
ord-baf86cf0c6d44c41950b44847c022c14
Source dataset
uspto-grants-2015_06
Patent number
US09045479B2

Reaction notes

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