Hydrochloric Acid → HCID 117772329, compound

HRID 2167778Notes

Reaction equation

HRID 2167778 reaction equation
[ClH:1].[OH:2][CH2:3][CH2:4][N:5]1[CH2:9][CH2:8][C@H:7]([NH:10]C(=O)OC(C)(C)C)[CH2:6]1>O1CCOCC1>[ClH:1].[NH2:10][C@H:7]1[CH2:8][CH2:9][N:5]([CH2:4][CH2:3][OH:2])[CH2:6]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 66565985HCID 66565985, compound

Product 1

HCID 117772329HCID 117772329, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

4M HCl solution (in dioxane) (1.5 mL) was added to a stirred solution of (S)-tert-butyl (1-(2-hydroxyethyl)pyrrolidin-3-yl)carbamate (400 mg, 1.73 mmol) in Dioxane (1 mL) and stirring was continued at 20-35° C. for 2 h. After which the reaction mixture was concentrated under reduced pressure to afford the crude. The crude obtained was purified by washing with diethyl ether and dried to afford 300 mg (crude) of the title compound.

Workup

  1. concentrationAfter which the reaction mixture was concentrated under reduced pressure
  2. customto afford the crude
  3. customThe crude obtained
  4. customwas purified
  5. washby washing with diethyl ether
  6. customdried

Sources & evidence

ORD record
ord-0569b873f7034d5cb8be977143540f47
Source dataset
uspto-grants-2015_06
Patent number
US09045479B2

Reaction notes

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