Hydrochloric Acid → HCID 66672546, compound

HRID 2167783Notes

Reaction equation

HRID 2167783 reaction equation
[ClH:1].[CH3:2][S:3]([N:6]1[CH2:10][CH2:9][C@H:8]([NH:11]C(=O)OC(C)(C)C)[CH2:7]1)(=[O:5])=[O:4]>>[ClH:1].[CH3:2][S:3]([N:6]1[CH2:10][CH2:9][C@H:8]([NH2:11])[CH2:7]1)(=[O:5])=[O:4]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 589598791,1-Dimethylethyl N-[(3S)-1-(methylsulfonyl)-3-pyrrolidinyl]carbamate

Product 1

HCID 66672546HCID 66672546, compound

Procedure

4M HCl solution (in Dioxane) (2 mL) and (S)-tert-butyl (1-(methylsulfonyl)pyrrolidin-3-yl)carbamate (200 mg, 0.99 mmol) was stirred at 20-35° C. for 2 h. The solid precipitate thus obtained was filtered, washed with hexane and dried to afford 120 mg of the title compound.

Workup

  1. customThe solid precipitate thus obtained
  2. filtrationwas filtered
  3. washwashed with hexane
  4. customdried

Sources & evidence

ORD record
ord-97ea739a9be6439b807611b19984e593
Source dataset
uspto-grants-2015_06
Patent number
US09045479B2

Reaction notes

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