Trifluoroacetic acid → HCID 178511581, compound

HRID 2167968Notes

Reaction equation

HRID 2167968 reaction equation
C(OC(=O)[NH:7][C@H:8]1[CH2:13][CH2:12][C@@H:11]([N:14]2[CH2:19][CH2:18][O:17][CH2:16][CH2:15]2)[CH2:10][CH2:9]1)(C)(C)C.[F:21][C:22]([F:27])([F:26])[C:23]([OH:25])=[O:24]>ClCCl>[F:21][C:22]([F:27])([F:26])[C:23]([OH:25])=[O:24].[F:21][C:22]([F:27])([F:26])[C:23]([OH:25])=[O:24].[O:17]1[CH2:16][CH2:15][N:14]([C@@H:11]2[CH2:10][CH2:9][C@H:8]([NH2:7])[CH2:13][CH2:12]2)[CH2:19][CH2:18]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 178453984HCID 178453984, compound

Product 1

HCID 178511581HCID 178511581, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of EXAMPLE 39A (2.43 g) in dichloromethane (15 ml) was added trifluoroacetic acid (5 ml) and the reaction mixture was stirred for 16 hours at room temperature. The reaction mixture was concentrated and the crude product was used without purification.

Workup

  1. concentrationThe reaction mixture was concentrated
  2. customthe crude product was used without purification

Sources & evidence

ORD record
ord-c0a990c6d0a2462ab1d148ea31676205
Source dataset
uspto-grants-2015_06
Patent number
US09045475B2

Reaction notes

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