4-(benzylamino)tetrahydro-2H-thiopyran 1,1-dioxide → 2H-Thiopyran-4-amine, tetrahydro-, 1,1-dioxide

HRID 2167981Notes

Reaction equation

HRID 2167981 reaction equation
C([NH:8][CH:9]1[CH2:14][CH2:13][S:12](=[O:16])(=[O:15])[CH2:11][CH2:10]1)C1C=CC=CC=1.[H][H]>[OH-].[OH-].[Pd+2].C(O)C>[O:15]=[S:12]1(=[O:16])[CH2:13][CH2:14][CH:9]([NH2:8])[CH2:10][CH2:11]1

Participants

5

Reactant 2

HCID 247300404-(benzylamino)tetrahydro-2H-thiopyran 1,1-dioxideHCID 178418361HCID 178418361, compound

Product 1

HCID 4188082H-Thiopyran-4-amine, tetrahydro-, 1,1-dioxide

Reagents, catalysts & solvents 2

HCID 9942167Palladium hydroxideCatalystHCID 702EthanolSolvent

Procedure

N-Benzyl-1,1-dioxotetrahydro-2H-thiopyran-4-amine (2.00 g) was added to ethanol (40 mL) in a pressure bottle. Palladium hydroxide on carbon (0.587 g,) was added and the solution was stirred under 30 psi of hydrogen at room temperature for 2 hours. The mixture was filtered through a nylon membrane and the solvent was removed under vacuum.

Workup

  1. filtrationThe mixture was filtered through a nylon membrane
  2. customthe solvent was removed under vacuum

Sources & evidence

ORD record
ord-f430c82af1ba45ab803ae3024c61bc92
Source dataset
uspto-grants-2015_06
Patent number
US09045475B2

Reaction notes

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