Hydrochloric Acid → 3-Nitro-4-(piperidin-4-ylamino)benzenesulfonamide

HRID 2167983Notes

Reaction equation

HRID 2167983 reaction equation
[N+:1]([C:4]1[CH:9]=[C:8]([S:10](=[O:13])(=[O:12])[NH2:11])[CH:7]=[CH:6][C:5]=1[NH:14][CH:15]1[CH2:20][CH2:19][N:18](C(OC(C)(C)C)=O)[CH2:17][CH2:16]1)([O-:3])=[O:2].Cl>ClCCl.CCOCC>[N+:1]([C:4]1[CH:9]=[C:8]([S:10]([NH2:11])(=[O:12])=[O:13])[CH:7]=[CH:6][C:5]=1[NH:14][CH:15]1[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]1)([O-:3])=[O:2]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 67126453HCID 67126453, compound

Product 1

HCID 433458063-Nitro-4-(piperidin-4-ylamino)benzenesulfonamide

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 6344DichloromethaneSolvent

Procedure

Tert-butyl 4-(2-nitro-4-sulfamoylphenylamino)piperidine-1-carboxylate was dissolved in dichloromethane (3 mL) and treated with 1N HCl in ether (4 mL). The reaction was stirred overnight then concentrated to give the title compound.

Workup

  1. concentrationthen concentrated

Sources & evidence

ORD record
ord-0e9d9f9213ba4287a8279fe767477070
Source dataset
uspto-grants-2015_06
Patent number
US09045475B2

Reaction notes

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