Tetrahydro-4H-pyran-4-one → (S)-tert-butyl 1-(tetrahydro-2H-pyran-4-yl)piperidin-3-ylcarbamate

HRID 2167988Notes

Reaction equation

HRID 2167988 reaction equation
[N:1]1([C:7]([O:9][C:10]([CH3:13])([CH3:12])[CH3:11])=[O:8])[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[O:14]1[CH2:19][CH2:18][C:17](=O)[CH2:16][CH2:15]1.Cl[C:22]1C=CC(C2C(C=O)=CC=CC=2)=CC=1>>[O:14]1[CH2:19][CH2:18][CH:17]([N:4]2[CH2:3][CH2:2][CH2:22][C@H:6]([NH:1][C:7](=[O:8])[O:9][C:10]([CH3:11])([CH3:12])[CH3:13])[CH2:5]2)[CH2:16][CH2:15]1

Participants

4

Reactant 3

HCID 121599Tetrahydro-4H-pyran-4-oneHCID 143452tert-Butyl piperazine-1-carboxylateHCID 13936894'-Chlorobiphenyl-2-carbaldehyde

Product 1

HCID 67126493(S)-tert-butyl 1-(tetrahydro-2H-pyran-4-yl)piperidin-3-ylcarbamate

Procedure

The title compound was prepared by substituting (S)-tert-butyl piperidin-3-ylcarbamate for tert-butyl piperazine-1-carboxylate and dihydro-2H-pyran-4(3H)-one for 4′-chlorobiphenyl-2-carboxaldehyde in EXAMPLE 1A.

Sources & evidence

ORD record
ord-9636079f2fda4b4b885c9b2bd0c51901
Source dataset
uspto-grants-2015_06
Patent number
US09045475B2

Reaction notes

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