Hydrochloric Acid → HCID 79005005, compound

HRID 2168028Notes

Reaction equation

HRID 2168028 reaction equation
[F:1][CH:2]([F:17])[CH2:3][N:4]1[CH2:8][CH2:7][C@@H:6]([NH:9]C(=O)OC(C)(C)C)[CH2:5]1.Cl>ClCCl.CO.O1CCOCC1>[F:1][CH:2]([F:17])[CH2:3][N:4]1[CH2:8][CH2:7][C@@H:6]([NH2:9])[CH2:5]1

Participants

6

Reactant 2

HCID 313Hydrochloric AcidHCID 86642506HCID 86642506, compound

Product 1

HCID 79005005HCID 79005005, compound

Reagents, catalysts & solvents 3

HCID 887MethanolSolventHCID 6344DichloromethaneSolventHCID 312751,4-DioxaneSolvent

Procedure

To a solution of EXAMPLE 180A (525 mg) in a mixture of dichloromethane (3 mL) and methanol (4.0 mL) was added hydrogen chloride, 4M in dioxane (5.24 mL) and the reaction was stirred for 1.5 hours. The reaction was concentrated and the crude material was taken up in dichloromethane and the solvent evaporated, then taken up in ether and the solvent evaporated, and then dried on high vacuum.

Workup

  1. concentrationThe reaction was concentrated
  2. customthe solvent evaporated
  3. customthe solvent evaporated
  4. customdried on high vacuum

Sources & evidence

ORD record
ord-9235b63f7e6d418b81c8aab204dc665d
Source dataset
uspto-grants-2015_06
Patent number
US09045475B2

Reaction notes

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