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To 50 ml of acetone were added 2.46 g of o-anisidine and 3.75 g of benzoyl isothiocyanate, and the mixture is stirred under reflux for 2 hours and, then, allowed to stand overnight in a refrigerator at 5° C. The resulting crystals were collected by filtration, washed with cold acetone and dried under reduced pressure. The crystals were added to 50 ml of 30% methylamine-methanol and the mixture was stirred at room temperature overnight. The reaction mixture was concentrated to dryness under reduced pressure, and the residue was washed with ethanol-ethyl acetate and dried under reduced pressure. The procedure provided 2.08 g of N-(o-methoxyphenyl)thiourea.

1. temperatureunder reflux for 2 hours
2. filtrationThe resulting crystals were collected by filtration
3. washwashed with cold acetone
4. customdried under reduced pressure
5. additionThe crystals were added to 50 ml of 30% methylamine-methanol
6. stirringthe mixture was stirred at room temperature overnight
7. concentrationThe reaction mixture was concentrated to dryness under reduced pressure
8. washthe residue was washed with ethanol-ethyl acetate
9. customdried under reduced pressure