Trifluoroacetic acid → HCID 67126745, compound

HRID 2168142Notes

Reaction equation

HRID 2168142 reaction equation
[C:1]([C:3]1([CH3:18])[CH2:8][CH2:7][CH:6]([CH2:9][NH:10]C(=O)OC(C)(C)C)[CH2:5][CH2:4]1)#[N:2].FC(F)(F)C(O)=O>ClCCl>[NH2:10][CH2:9][CH:6]1[CH2:7][CH2:8][C:3]([CH3:18])([C:1]#[N:2])[CH2:4][CH2:5]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86648183HCID 86648183, compound

Product 1

HCID 67126745HCID 67126745, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of EXAMPLE 366A (480 mg) in dichloromethane (10 mL) was added trifluoroacetic acid (10 mL). The mixture was stirred for 3 hours. The mixture was then concentrated under vacuum and was used directly in the next reaction without further purification.

Workup

  1. concentrationThe mixture was then concentrated under vacuum
  2. customwas used directly in the next reaction without further purification

Sources & evidence

ORD record
ord-89065fb26daa4caaac92fac10a4b914e
Source dataset
uspto-grants-2015_06
Patent number
US09045475B2

Reaction notes

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