反应详情

温度

2.5 °C

2-Trimethylsilanyl-furo[3,2-b]pyridine (268 g, 0.14 mol) is dissolved in dichloromethane (3 l) and stirred at 0-5° C. To the solution is added 3-chloroperbenzoic acid over 30 min, stirred 1 h and warmed up to room temperature. After 14 h the reaction mixture is extracted with NaHCO3 solution and water. The organic layer is separated and dried over Na2SO4. The drying agent is filtered and the solvent is removed in vacuum; yield: 296 g 2-trimethylsilanyl-furo[3,2-b]pyridine 4-oxide; HPLC/MS: 2.0 min, [M+H]=208;

1. stirringstirred 1 h
2. temperaturewarmed up to room temperature
3. extractionAfter 14 h the reaction mixture is extracted with NaHCO3 solution and water
4. customThe organic layer is separated
5. dry with materialdried over Na2SO4
6. filtrationThe drying agent is filtered
7. customthe solvent is removed in vacuum
8. custom2.0 min, [M+H]=208