Trifluoroacetic acid → HCID 67988153, compound

HRID 2168209Notes

Reaction equation

HRID 2168209 reaction equation
[CH3:1][O:2][CH2:3][CH:4]1[CH:9]([NH:10][C:11]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[O:12])[CH2:8][CH2:7][N:6](C(OC(C)(C)C)=O)[CH2:5]1.FC(F)(F)C(O)=O>ClCCl>[CH3:1][O:2][CH2:3][CH:4]1[CH:9]([NH:10][C:11](=[O:12])[C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH2:8][CH2:7][NH:6][CH2:5]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 67988194HCID 67988194, compound

Product 1

HCID 67988153HCID 67988153, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

1,1-dimethylethyl 3-[(methyloxy)methyl]-4-[(phenylcarbonyl)amino]-1-piperidinecarboxylate D34 (0.8 g) was dissolved in dichloromethane (25 ml). Trifluoroacetic acid (10 ml) was then added dropwise at room temperature. The reaction mixture was then stirred at room temperature for 3 hours, solvent was removed. A light yellow oil was obtained of desired product D35 in 0.6 g. LCMS [M+H] [email protected] min (5 min run)

Workup

  1. customsolvent was removed

Sources & evidence

ORD record
ord-0cfd9dea91af4307b2a09fa6a166c320
Source dataset
uspto-grants-2015_06
Patent number
US09045485B2

Reaction notes

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