反应详情

N-{1-[5-bromo-7-(phenylsulfonyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-4-piperidinyl}-N-methyl-4-pyridinecarboxamide D26 (41 mg) was dissolved with Tetrahydrofuran (THF) (1 mL) and Methanol (0.500 mL). Cesium carbonate (72.2 mg, 0.221 mmol) was added. The mixture was stirred at room temperature for 30 min. The mixture was partitioned between ethyl acetate (15 mL) and water (5 mL). The aqueous layer was extracted with ethyl acetate (15 mL). The combined organic phase was filtered by a phase separator and the solvent was removed in vacuo. The crude material was purified by MDAP. Evaporated the solvent and put in the vacuum oven to give the product E39 in 0.0168 g as a white powder. LCMS [M+H]+414.94/416.94@1.86 min (5 min run)

1. customThe mixture was partitioned between ethyl acetate (15 mL) and water (5 mL)
2. extractionThe aqueous layer was extracted with ethyl acetate (15 mL)
3. filtrationThe combined organic phase was filtered by a phase separator
4. customthe solvent was removed in vacuo
5. customThe crude material was purified by MDAP
6. customEvaporated the solvent
7. customto give the product
8. customLCMS [M+H]+414.94/416.94@1.86 min (5 min run)