HCID 86710212, compound → HCID 178510332, compound

HRID 2168253Notes

Reaction equation

HRID 2168253 reaction equation
[C:1]([C:3]1[C:11]2[C:10]([N:12]3[CH2:17][CH2:16][CH:15]([NH:18][C:19](=[O:26])[C:20]4[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=4)[CH2:14][CH2:13]3)=[N:9][CH:8]=[N:7][C:6]=2[N:5](COCC[Si](C)(C)C)[CH:4]=1)#[N:2]>CC#N>[C:1]([C:3]1[C:11]2[C:6]([NH:7][CH:8]=[N:9][C:10]=2[N:12]2[CH2:13][CH2:14][CH:15]([NH:18][C:19](=[O:26])[C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[CH2:16][CH2:17]2)=[N:5][CH:4]=1)#[N:2]

Participants

3

Reactant 1

HCID 86710212HCID 86710212, compound

Product 1

HCID 178510332HCID 178510332, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Conditions

Temperature
80 °C

Procedure

N-{1-[5-cyano-7-({[2-(trimethylsilyl)ethyl]oxy}methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-4-piperidinyl}benzamide D44 (69 mg) and LiBF4 (85 mg, 0.9 mmol) were dissolved in MeCN (10 ml) and then the reaction mixture was heated at 80° C. for 16 hours.

Sources & evidence

ORD record
ord-19a9f86acbf341768efa6e7ea9e4095b
Source dataset
uspto-grants-2015_06
Patent number
US09045485B2

Reaction notes

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