Water → HCID 67226454, compound

HRID 2168425Notes

Reaction equation

HRID 2168425 reaction equation
[O:1]1[C:5]2([CH2:10][CH2:9][NH:8][CH2:7][CH2:6]2)[O:4][CH2:3][CH2:2]1.F[C:12]1[CH:21]=[CH:20][C:15]([C:16]([O:18][CH3:19])=[O:17])=[C:14]([O:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[CH:13]=1.C([O-])([O-])=O.[K+].[K+].O>CS(C)=O>[O:22]([C:14]1[CH:13]=[C:12]([N:8]2[CH2:9][CH2:10][C:5]3([O:4][CH2:3][CH2:2][O:1]3)[CH2:6][CH2:7]2)[CH:21]=[CH:20][C:15]=1[C:16]([O:18][CH3:19])=[O:17])[C:23]1[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=1

Participants

6

Reactant 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 674351,4-Dioxa-8-azaspiro(4.5)decaneHCID 67144536Benzoic acid, 4-fluoro-2-phenoxy-, methyl ester

Product 1

HCID 67226454HCID 67226454, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

1,4-dioxa-8-azaspiro[4.5]decane (1.18 g), methyl 4-fluoro-2-phenoxybenzoate (1.85 g), and K2CO3 (1.14 g) was stirred at 125° C. in dimethylsulfoxide (25 mL) for 24 hours. The mixture was cooled, poured into 300 mL water, extracted three times with ether, and the ether extracts were combined, rinsed three times with water, and brine, and concentrated. The residue was chromatographed on silica gel using 10-30% ethyl acetate in hexanes as eluent to give the title compound.

Workup

  1. temperatureThe mixture was cooled
  2. extractionextracted three times with ether
  3. washrinsed three times with water, and brine
  4. concentrationconcentrated
  5. customThe residue was chromatographed on silica gel using 10-30% ethyl acetate in hexanes as eluent

Sources & evidence

ORD record
ord-36cfed334b4d4dd7898855e910eae64c
Source dataset
uspto-grants-2015_06
Patent number
US09045420B2

Reaction notes

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