Sodium Carbonate → HCID 67226454, compound

HRID 2168426Notes

Reaction equation

HRID 2168426 reaction equation
F[C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[C:4]([O:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH:3]=1.[O:19]1[C:23]2([CH2:28][CH2:27][NH:26][CH2:25][CH2:24]2)[O:22][CH2:21][CH2:20]1.C(=O)([O-])[O-].[Na+].[Na+]>C(OCC)(=O)C>[O:12]([C:4]1[CH:3]=[C:2]([N:26]2[CH2:27][CH2:28][C:23]3([O:22][CH2:21][CH2:20][O:19]3)[CH2:24][CH2:25]2)[CH:11]=[CH:10][C:5]=1[C:6]([O:8][CH3:9])=[O:7])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

Participants

5

Reactant 3

HCID 10340Sodium CarbonateHCID 674351,4-Dioxa-8-azaspiro(4.5)decaneHCID 67144536Benzoic acid, 4-fluoro-2-phenoxy-, methyl ester

Product 1

HCID 67226454HCID 67226454, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Conditions

Temperature
130 °C

Procedure

Methyl 4-fluoro-2-phenoxybenzoate (2 g) and 1,4-dioxa-8-azaspiro[4.5]decane (1.279 g) were combined in dimethylsulfoxideO (12 mL) in a 250 mL round-bottom flask. Sodium carbonate (1.291 g) was added. The reaction flask was sealed and heated to 130° C. overnight. The reaction mixture was diluted with ethyl acetate, washed thoroughly with water and with brine, and dried over MgSO4, filtered and concentrated to obtain the desired product.

Workup

  1. customThe reaction flask was sealed
  2. washwashed thoroughly with water and with brine
  3. dry with materialdried over MgSO4
  4. filtrationfiltered
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-7a8616fde2604ba4881eb1c69a495eb2
Source dataset
uspto-grants-2015_06
Patent number
US09045420B2

Reaction notes

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