Hydrochloric Acid → 4-(4-Benzyloxy-phenyl)-3-butyl-6-(piperidin-4-ylmethoxy)-pyridazine dihydrochloride

HRID 2168596Notes

Reaction equation

HRID 2168596 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][O:15][C:16]2[N:17]=[N:18][C:19]([CH2:36][CH2:37][CH2:38][CH3:39])=[C:20]([C:22]3[CH:27]=[CH:26][C:25]([O:28][CH2:29][C:30]4[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=4)=[CH:24][CH:23]=3)[CH:21]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:40]>O1CCOCC1>[ClH:40].[ClH:40].[CH2:29]([O:28][C:25]1[CH:24]=[CH:23][C:22]([C:20]2[CH:21]=[C:16]([O:15][CH2:14][CH:11]3[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]3)[N:17]=[N:18][C:19]=2[CH2:36][CH2:37][CH2:38][CH3:39])=[CH:27][CH:26]=1)[C:30]1[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 673730694-[5-(4-Benzyloxy-phenyl)-6-butyl-pyridazin-3-yloxymethyl]-piperidine-1-carboxylic acid tert-butyl ester

Product 1

HCID 673740144-(4-Benzyloxy-phenyl)-3-butyl-6-(piperidin-4-ylmethoxy)-pyridazine dihydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

4-[5-(4-Benzyloxy-phenyl)-6-butyl-pyridazin-3-yloxymethyl]-piperidine-1-carboxylic acid tert-butyl ester (0.47 mmol, 250 mg) was dissolved in 4.0 M HCl in dioxane and stirred for 45 min at room temperature. The solvent was evaporated and the resultant solid was washed with ether and dried to provide 4-(4-benzyloxy-phenyl)-3-butyl-6-(piperidin-4-ylmethoxy)-pyridazine dihydrochloride.

Workup

  1. customThe solvent was evaporated
  2. washthe resultant solid was washed with ether
  3. customdried

Sources & evidence

ORD record
ord-100ecd12558f4a6ebfc6df129fc8e416
Source dataset
uspto-grants-2015_06
Patent number
US09045461B2

Reaction notes

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