Hydrochloric Acid → HCID 86657790, compound

HRID 2168654Notes

Reaction equation

HRID 2168654 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][C@H:11]([CH2:14][O:15][C:16]2[N:17]=[N:18][C:19]([CH2:35][CH2:36][CH2:37][CH3:38])=[C:20]([C:22]3[CH:27]=[CH:26][C:25]([O:28][CH:29]4[CH2:34][CH2:33][CH2:32][CH2:31][CH2:30]4)=[CH:24][CH:23]=3)[CH:21]=2)[C@H:10]([O:39][CH3:40])[CH2:9]1)=O)(C)(C)C.[ClH:41]>C(Cl)Cl.O1CCOCC1>[ClH:41].[ClH:41].[CH2:35]([C:19]1[N:18]=[N:17][C:16]([O:15][CH2:14][C@H:11]2[CH2:12][CH2:13][NH:8][CH2:9][C@H:10]2[O:39][CH3:40])=[CH:21][C:20]=1[C:22]1[CH:23]=[CH:24][C:25]([O:28][CH:29]2[CH2:30][CH2:31][CH2:32][CH2:33][CH2:34]2)=[CH:26][CH:27]=1)[CH2:36][CH2:37][CH3:38]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 86657789HCID 86657789, compound

Product 1

HCID 86657790HCID 86657790, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 312751,4-DioxaneSolvent

Procedure

To a solution of (±)-cis-4-[6-butyl-5-(4-cyclohexyloxy-phenyl)-pyridazin-3-yloxymethyl]-3-methoxy-piperidine-1-carboxylic acid tert-butyl ester (0.36 mmol, 0.20 g) in DCM (1 mL) was added 4 N HCl in dioxane (1 mL). The solution was stirred for 1 hour. The solvents were removed with reduced pressure and the salt was triturated with diethyl ether and filtered to give (±)-cis-3-butyl-4-(4-cyclohexyloxy-phenyl)-6-(3-methoxy-piperidin-4-ylmethoxy)-pyridazine dihydrochloride (0.17 g).

Workup

  1. customThe solvents were removed with reduced pressure
  2. customthe salt was triturated with diethyl ether
  3. filtrationfiltered

Sources & evidence

ORD record
ord-6032d394328e48dfbd93fa348692414b
Source dataset
uspto-grants-2015_06
Patent number
US09045461B2

Reaction notes

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