Hydrochloric Acid → HCID 67372091, compound

HRID 2168719Notes

Reaction equation

HRID 2168719 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([O:14][C:15]2[N:16]=[N:17][C:18]([CH:34]3[CH2:37][CH2:36][CH2:35]3)=[C:19]([C:21]3[CH:26]=[CH:25][C:24]([O:27][CH:28]4[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]4)=[CH:23][CH:22]=3)[CH:20]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:38]>C(Cl)Cl.O1CCOCC1>[ClH:38].[ClH:38].[CH:34]1([C:18]2[N:17]=[N:16][C:15]([O:14][CH:11]3[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]3)=[CH:20][C:19]=2[C:21]2[CH:22]=[CH:23][C:24]([O:27][CH:28]3[CH2:29][CH2:30][CH2:31][CH2:32][CH2:33]3)=[CH:25][CH:26]=2)[CH2:37][CH2:36][CH2:35]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 67373305HCID 67373305, compound

Product 1

HCID 67372091HCID 67372091, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 312751,4-DioxaneSolvent

Procedure

To a solution of 4-[6-cyclobutyl-5-(4-cyclohexyloxy-phenyl)-pyridazin-3-yloxy]-piperidine-1-carboxylic acid tert-butyl ester (0.35 mmol, 0.18 g) in DCM (1.0 mL) was added 4 N HCl in dioxane (1.0 mL) and the reaction was stirred for 30 min. The solvents were removed under reduced pressure and the residue was triturated with anhydrous ethyl ether and filtered to give 3-cyclobutyl-4-(4-cyclohexyloxy-phenyl)-6-(piperidin-4-yloxy)-pyridazine dihydrochloride (0.14 g).

Workup

  1. customThe solvents were removed under reduced pressure
  2. customthe residue was triturated with anhydrous ethyl ether
  3. filtrationfiltered

Sources & evidence

ORD record
ord-54ca3185d0304585a225f0b803b497d0
Source dataset
uspto-grants-2015_06
Patent number
US09045461B2

Reaction notes

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