cis-4-Azidomethyl-1-tert-butoxycarbonyl-3-hydroxypiperidine → cis-4-Azidomethyl-piperidin-3-ol

HRID 2168792Notes

Reaction equation

HRID 2168792 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][C@H:11]([CH2:14][N:15]=[N+:16]=[N-:17])[C@H:10]([OH:18])[CH2:9]1)=O)(C)(C)C>ClCCl.Cl>[N:15]([CH2:14][C@H:11]1[CH2:12][CH2:13][NH:8][CH2:9][C@H:10]1[OH:18])=[N+:16]=[N-:17]

Participants

4

Reactant 1

HCID 86657830cis-4-Azidomethyl-1-tert-butoxycarbonyl-3-hydroxypiperidine

Product 1

HCID 86657829cis-4-Azidomethyl-piperidin-3-ol

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 6344DichloromethaneSolvent

Procedure

A solution of cis-4-azidomethyl-3-hydroxy-piperidine-1-carboxylic acid tert-butyl ester (1.4 mmol, 360 mg) in dichloromethane (1 mL) and 4N HCl (2 mL) was stirred at room temperature for 2 h. Solvent was evaporated to give cis-4-azidomethyl-piperidin-3-ol and was used without further purification.

Workup

  1. customSolvent was evaporated

Sources & evidence

ORD record
ord-f9d5755700604cfc972d9aeb485b16e7
Source dataset
uspto-grants-2015_06
Patent number
US09045461B2

Reaction notes

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