反应详情

(S)-tert-Butyl 1-amino-3-(4-iodophenyl)-1-oxopropan-2-ylcarbamate (Example 1, step (i), 2.41 g) was stirred in dichloromethane (125 mL) and to the suspension was added trifluoroacetic acid (8 mL). The mixture was stirred for 2 h and then concentrated to ˜12 mL in vacuo. The residue was stirred for 2 days, dissolved in ethyl acetate/dichloromethane and washed with water containing an excess of sodium bicarbonate. The organic layer was dried and evaporated to the sub-titled compound (1.52 g).

1. concentrationconcentrated to ˜12 mL in vacuo
2. stirringThe residue was stirred for 2 days
3. dissolutiondissolved in ethyl acetate/dichloromethane
4. washwashed with water containing an excess of sodium bicarbonate
5. customThe organic layer was dried
6. customevaporated to the sub-titled compound (1.52 g)