Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2169117Generated: November 3, 2026

Diethyl Carbonate → Ivabradine impurity 9

https://huagongshe.com/reaction/2169117

Reaction equation

Participants

RoleNameHCIDCharge
ReactantDiethyl CarbonateHCID 7766—
Reactant(3,4-Dimethoxy-bicyclo[4.2.0]octa-1,3,5-trien-7-yl)-methylamineHCID 423512—
Solvent2-MethyltetrahydrofuranHCID 7301—
ProductIvabradine impurity 9HCID 23590135—

Reaction Steps

5 mg of 1-(3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methanamine and 12.6 mg (10 eq) of diethyl carbonate are dissolved in 2-MeTHF.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09045788B2
Source datasetuspto-grants-2015_06
ORD IDord-4c2239621b654b839d32fd82a1c9ed0a
Source noteuspto-grants-2015_06