HCID 178450817, compound → 2-[[2-(2-chlorophenyl)phenyl]methyl]-4-oxo-5-phenylmethoxy-1H-pyrimidine-6-carboxylic acid

HRID 2169130Notes

Reaction equation

HRID 2169130 reaction equation
C([O:5][C:6]([C:8]1[C:13]([O:14][CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[C:12]([OH:22])[N:11]=[C:10]([CH2:23][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=2[C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][C:31]=2[Cl:36])[N:9]=1)=[O:7])(C)(C)C.C(OC1C(C(O)=O)=NC(CC2C=CC=CC=2C2C=CC=CC=2)=NC=1O)C1C=CC=CC=1>>[CH2:15]([O:14][C:13]1[C:8]([C:6]([OH:7])=[O:5])=[N:9][C:10]([CH2:23][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=2[C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][C:31]=2[Cl:36])=[N:11][C:12]=1[OH:22])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

Participants

3

Reactant 2

HCID 178450817HCID 178450817, compoundHCID 178524878HCID 178524878, compound

Product 1

HCID 1785248772-[[2-(2-chlorophenyl)phenyl]methyl]-4-oxo-5-phenylmethoxy-1H-pyrimidine-6-carboxylic acidYield 67.53%

Procedure

5-Benzyloxy-2-(2′-chloro-biphenyl-2-ylmethyl)-6-hydroxypyrimidine-4-carboxylic acid (7-02) (3 g, 67.53%) was synthesized as a white solid from 5-benzyloxy-2-(2′-chloro-biphenyl-2-ylmethyl)-6-hydroxypyrimidine-4-carboxylic acid tert-butyl ester (6-02) (5 g, 9.94 mmol) following the procedure as described for 5-benzyloxy-2-biphenyl-2-ylmethyl-6-hydroxypyrimidine-4-carboxylic acid (7-01).

Sources & evidence

ORD record
ord-a95bdf72082c44578207f36ab3cf8e8e
Source dataset
uspto-grants-2015_06
Patent number
US09045486B2

Reaction notes

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