HuagongsheHuagongshe Chemistry Print Report · For research reference only
9-Benzyloxy-6-(2'-chloro-biphenyl-2-ylmethyl)-2-methyl-3,4-dihydro-2H-pyrazino[1,2-c]pyrimidine-1,8-dione → 6-(2'-Chloro-biphenyl-2-ylmethyl)-9-hydroxy-2-methyl-3,4-dihydro-2H-pyrazino[1,2-c]pyrimidine-1,8-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 9-Benzyloxy-6-(2'-chloro-biphenyl-2-ylmethyl)-2-methyl-3,4-dihydro-2H-pyrazino[1,2-c]pyrimidine-1,8-dione | HCID 86725798 | — |
| Reactant | 6-biphenyl-2-ylmethyl-9-hydroxy-2-methyl-3,4-dihydro-2H-pyrazino[1,2-c]pyrimidine-1,8-dione | HCID 86725801 | — |
| Product | 6-(2'-Chloro-biphenyl-2-ylmethyl)-9-hydroxy-2-methyl-3,4-dihydro-2H-pyrazino[1,2-c]pyrimidine-1,8-dione | HCID 86725802 | 61.2% |
Reaction Steps
6-(2′-Chloro-biphenyl-2-ylmethyl)-9-hydroxy-2-methyl-3,4-dihydro-2H-pyrazino[1,2-c]pyrimidine-1,8-dione (12-02) (215 mg, 58.54%) was synthesized as an off-white solid from 9-benzyloxy-6-(2′-chloro-biphenyl-2-ylmethyl)-2-methyl-3,4-dihydro-2H-pyrazino[1,2-c]pyrimidine-1,8-dione (11-02) (400 mg, 0.887 mmol) following the procedure as described for 6-biphenyl-2-ylmethyl-9-hydroxy-2-methyl-3,4-dihydro-2H-pyrazino[1,2-c]pyrimidine-1,8-dione (12-01).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09045486B2 |
| Source dataset | uspto-grants-2015_06 |
| ORD ID | ord-c35615802e23480389736ca1a290a299 |
| Source note | uspto-grants-2015_06 |