反应详情

To a stirred solution of 1-phenyl-cyclopentyl)-methanol (23-01) (9.1 gm, 51.70 mmol) in dichloromethane (100 mL) was added triethyl amine (14.4 mL, 104.96 mmol) followed by methanesulfonyl chloride (5.09 ml, 62.045 mmol) at cooling condition, it was stirred at room temperature for 16 h. After completion of the reaction, the mixture was diluted with dichloromethane, washed with water, sodium bicarbonate solution and brine. The separated organic part was dried over sodium sulfate and evaporated under reduced pressure to get methanesulfonic acid 1-phenyl-cyclopentylmethyl ester (24-01) (13 g) as a crude product.

1. temperatureat cooling condition, it
2. customAfter completion of the reaction
3. washwashed with water, sodium bicarbonate solution and brine
4. dry with materialThe separated organic part was dried over sodium sulfate
5. customevaporated under reduced pressure