9-benzyloxy-2-isopropyl-6-(3-phenyl-pyridin-2-ylmethyl)-3,4-dihydro-2H-pyrazino[1,2-c]pyrimidine-1,8-dione → 9-Benzyloxy-8-hydroxy-2-isopropyl-6-(2-pyridyl)-4,9a-dihydro-3H-pyrazino[1,2-c]pyrimidin-1-one

HRID 2169242Notes

Reaction equation

HRID 2169242 reaction equation
C(OC1C(=O)N=C(CC2C(C3C=CC=CC=3)=CC=CN=2)N2CCN(C(C)C)C(=O)C=12)C1C=CC=CC=1.[CH2:37]([O:44][C:45]1[C:46]([C:58]([N:60]([CH2:64][CH2:65]O)[CH:61]([CH3:63])[CH3:62])=[O:59])=[N:47][C:48]([C:52]2[CH:57]=[CH:56][CH:55]=[CH:54][N:53]=2)=[N:49][C:50]=1[OH:51])[C:38]1[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=1>>[CH2:37]([O:44][C:45]1[CH:46]2[C:58](=[O:59])[N:60]([CH:61]([CH3:62])[CH3:63])[CH2:64][CH2:65][N:47]2[C:48]([C:52]2[CH:57]=[CH:56][CH:55]=[CH:54][N:53]=2)=[N:49][C:50]=1[OH:51])[C:38]1[CH:39]=[CH:40][CH:41]=[CH:42][CH:43]=1

Participants

3

Reactant 2

HCID 867258869-benzyloxy-2-isopropyl-6-(3-phenyl-pyridin-2-ylmethyl)-3,4-dihydro-2H-pyrazino[1,2-c]pyrimidine-1,8-dioneHCID 178457433HCID 178457433, compound

Product 1

HCID 867258919-Benzyloxy-8-hydroxy-2-isopropyl-6-(2-pyridyl)-4,9a-dihydro-3H-pyrazino[1,2-c]pyrimidin-1-one

Procedure

The title compound was prepared in analogy to (167) from 5-benzyloxy-6-hydroxy-N-(2-hydroxyethyl)-N-isopropyl-2-(2-pyridyl)pyrimidine-4-carboxamide (194) as a light yellow gum.

Sources & evidence

ORD record
ord-6d819c06b66b4d3096ffb4304fbc32d7
Source dataset
uspto-grants-2015_06
Patent number
US09045486B2

Reaction notes

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