9-hydroxy-2-isopropyl-6-[1-(4-trifluoromethyl-phenyl)-cyclopentylmethyl]-3,4-dihydro-2H-pyrazino[1,2-c]pyrimidine-1,8-dione → 9-Hydroxy-2-isopropyl-6-(2-pyridyl)-3,4-dihydropyrazino[1,2-c]pyrimidine-1,8-dione

HRID 2169243Notes

Reaction equation

HRID 2169243 reaction equation
OC1C(=O)N=C(CC2(C3C=CC(C(F)(F)F)=CC=3)CCCC2)N2CCN(C(C)C)C(=O)C=12.C([O:40][C:41]1[CH:42]2[C:57](=[O:58])[N:56]([CH:59]([CH3:61])[CH3:60])[CH2:55][CH2:54][N:43]2[C:44]([C:48]2[CH:53]=[CH:52][CH:51]=[CH:50][N:49]=2)=[N:45][C:46]=1[OH:47])C1C=CC=CC=1>>[OH:40][C:41]1[C:46](=[O:47])[N:45]=[C:44]([C:48]2[CH:53]=[CH:52][CH:51]=[CH:50][N:49]=2)[N:43]2[CH2:54][CH2:55][N:56]([CH:59]([CH3:61])[CH3:60])[C:57](=[O:58])[C:42]=12

Participants

3

Reactant 2

HCID 867258889-hydroxy-2-isopropyl-6-[1-(4-trifluoromethyl-phenyl)-cyclopentylmethyl]-3,4-dihydro-2H-pyrazino[1,2-c]pyrimidine-1,8-dioneHCID 867258919-Benzyloxy-8-hydroxy-2-isopropyl-6-(2-pyridyl)-4,9a-dihydro-3H-pyrazino[1,2-c]pyrimidin-1-one

Product 1

HCID 867258939-Hydroxy-2-isopropyl-6-(2-pyridyl)-3,4-dihydropyrazino[1,2-c]pyrimidine-1,8-dione

Procedure

The title compound was prepared in analogy to (168) from 9-benzyloxy-8-hydroxy-2-isopropyl-6-(2-pyridyl)-4,9a-dihydro-3H-pyrazino[1,2-c]pyrimidin-1-one (195) as an off-white solid.

Sources & evidence

ORD record
ord-5a96f87c424246a7a4fd8adb039ca91d
Source dataset
uspto-grants-2015_06
Patent number
US09045486B2

Reaction notes

Loading…