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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2169243Generated: October 30, 2026

9-hydroxy-2-isopropyl-6-[1-(4-trifluoromethyl-phenyl)-cyclopentylmethyl]-3,4-dihydro-2H-pyrazino[1,2-c]pyrimidine-1,8-dione → 9-Hydroxy-2-isopropyl-6-(2-pyridyl)-3,4-dihydropyrazino[1,2-c]pyrimidine-1,8-dione

https://huagongshe.com/reaction/2169243

Reaction equation

Participants

RoleNameHCIDCharge
Reactant9-hydroxy-2-isopropyl-6-[1-(4-trifluoromethyl-phenyl)-cyclopentylmethyl]-3,4-dihydro-2H-pyrazino[1,2-c]pyrimidine-1,8-dioneHCID 86725888—
Reactant9-Benzyloxy-8-hydroxy-2-isopropyl-6-(2-pyridyl)-4,9a-dihydro-3H-pyrazino[1,2-c]pyrimidin-1-oneHCID 86725891—
Product9-Hydroxy-2-isopropyl-6-(2-pyridyl)-3,4-dihydropyrazino[1,2-c]pyrimidine-1,8-dioneHCID 86725893—

Reaction Steps

The title compound was prepared in analogy to (168) from 9-benzyloxy-8-hydroxy-2-isopropyl-6-(2-pyridyl)-4,9a-dihydro-3H-pyrazino[1,2-c]pyrimidin-1-one (195) as an off-white solid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09045486B2
Source datasetuspto-grants-2015_06
ORD IDord-5a96f87c424246a7a4fd8adb039ca91d
Source noteuspto-grants-2015_06