反应详情

温度

70 °C

A mixture of 5-bromobenzo[d]oxazol-2(3H)-one (1.1 g), 3-methoxypropyl methanesulfonate (1.297 g) and potassium carbonate (2.131 g) in acetonitrile (25 mL) was heated at 70° C. for 16 h. Water was added and the mixture was extracted with ethyl acetate (3 times). The organic layers were dried (MgSO4), evaporated and purified by flash chromatography (silica, isohexane-acetone (5:1) as eluent) to give the sub-titled compound (1.50 g) as an oil.

1. extractionthe mixture was extracted with ethyl acetate (3 times)
2. dry with materialThe organic layers were dried (MgSO4)
3. customevaporated
4. custompurified by flash chromatography (silica, isohexane-acetone (5:1) as eluent)