HCID 178446422, compound → HCID 178446402, compound

HRID 2169337Notes

Reaction equation

HRID 2169337 reaction equation
C1(N(CCO)C(C2C(OCC3C=CC=CC=3)=C(O)N=C(CC3(C4C=CC=CC=4)CCCC3)N=2)=O)CC1.[Si]([O:44][CH2:45][CH2:46][N:47]([CH2:77][C:78]([CH3:81])([CH3:80])[CH3:79])[C:48]([C:50]1[C:55]([O:56][CH2:57][C:58]2[CH:63]=[CH:62][CH:61]=[CH:60][CH:59]=2)=[C:54]([OH:64])[N:53]=[C:52]([CH2:65][C:66]2([C:71]3[CH:76]=[CH:75][CH:74]=[CH:73][CH:72]=3)[CH2:70][CH2:69][CH2:68][CH2:67]2)[N:51]=1)=[O:49])(C(C)(C)C)(C)C>>[CH3:79][C:78]([CH3:81])([CH3:80])[CH2:77][N:47]([CH2:46][CH2:45][OH:44])[C:48]([C:50]1[C:55]([O:56][CH2:57][C:58]2[CH:63]=[CH:62][CH:61]=[CH:60][CH:59]=2)=[C:54]([OH:64])[N:53]=[C:52]([CH2:65][C:66]2([C:71]3[CH:76]=[CH:75][CH:74]=[CH:73][CH:72]=3)[CH2:70][CH2:69][CH2:68][CH2:67]2)[N:51]=1)=[O:49]

Participants

3

Reactant 2

HCID 178446422HCID 178446422, compoundHCID 178519962HCID 178519962, compound

Product 1

HCID 178446402HCID 178446402, compoundYield 94.8%

Procedure

This compound was prepared following the same method as described for 5-benzyloxy-6-hydroxy-2-(1-phenyl-cyclopentylmethyl)-pyrimidine-4-carboxylic acid cyclopropyl-(2-hydroxyethyl)-amide (285) from 5-benzyloxy-6-hydroxy-2-(1-phenyl-cyclopentylmethyl)-pyrimidine-4-carboxylic acid [2-(tert-butyl-dimethylsilanyloxy)-ethyl]-(2,2-dimethyl-propyl)-amide (300) (350 mg, 0.55 mmol). The product was obtained as a light yellow sticky solid (270 mg, 94.03%).

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-ea1df6086e1249c9ad8c8dd6a27d3c67
Source dataset
uspto-grants-2015_06
Patent number
US09045486B2

Reaction notes

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