反应详情

To 3-hydroxyphenylboronic acid (10 g) stirred in pyridine (40 mL) at 0° C. was added methanesulfonyl chloride (8 mL). The reaction mixture was stirred for 1 h at room temperature and then water and ethyl acetate was added. The organic layer was separated and the aqueous layer was extracted with ethyl acetate. The combined organic layers were washed with dilute HCl washed with brine, dried over magnesium sulfate. The resulting solid was recrystallizated from petroleum ether and ethyl acetate to give the sub-titled compound (12 g).

1. customThe organic layer was separated
2. extractionthe aqueous layer was extracted with ethyl acetate
3. washThe combined organic layers were washed with dilute HCl
4. washwashed with brine
5. dry with materialdried over magnesium sulfate