1,4-Dibromobutane → 1-[3,5-Bis(trifluoromethyl)phenyl]cyclopentanecarbonitrile

HRID 2169484Notes

Reaction equation

HRID 2169484 reaction equation
[F:1][C:2]([F:17])([F:16])[C:3]1[CH:4]=[C:5]([CH2:13][C:14]#[N:15])[CH:6]=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:8]=1.Br[CH2:19][CH2:20][CH2:21][CH2:22]Br.FC(F)(F)C1C=CC(C2(C#N)CCCC2)=CC=1>>[F:1][C:2]([F:16])([F:17])[C:3]1[CH:4]=[C:5]([C:13]2([C:14]#[N:15])[CH2:22][CH2:21][CH2:20][CH2:19]2)[CH:6]=[C:7]([C:9]([F:10])([F:11])[F:12])[CH:8]=1

Participants

4

Reactant 3

HCID 80561,4-DibromobutaneHCID 603657(3,5-Bis(trifluoromethyl)phenyl)acetonitrileHCID 218996241-(4-(Trifluoromethyl)phenyl)cyclopentanecarbonitrile

Product 1

HCID 102671981-[3,5-Bis(trifluoromethyl)phenyl]cyclopentanecarbonitrile

Procedure

1-(3,5-bis(trifluoromethyl)phenyl)cyclopentanecarbonitrile (455) was synthesized from 2-(3,5-bis(trifluoromethyl)phenyl)acetonitrile (454) and 1,4-dibromobutane following the procedure described for 1-(4-trifluoromethyl-phenyl)-cyclopentanecarbonitrile (237).

Sources & evidence

ORD record
ord-45278e337cb4481b8345cd07f9330637
Source dataset
uspto-grants-2015_06
Patent number
US09045486B2

Reaction notes

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