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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2169484Generated: October 31, 2026

1,4-Dibromobutane → 1-[3,5-Bis(trifluoromethyl)phenyl]cyclopentanecarbonitrile

https://huagongshe.com/reaction/2169484

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,4-DibromobutaneHCID 8056—
Reactant(3,5-Bis(trifluoromethyl)phenyl)acetonitrileHCID 603657—
Reactant1-(4-(Trifluoromethyl)phenyl)cyclopentanecarbonitrileHCID 21899624—
Product1-[3,5-Bis(trifluoromethyl)phenyl]cyclopentanecarbonitrileHCID 10267198—

Reaction Steps

1-(3,5-bis(trifluoromethyl)phenyl)cyclopentanecarbonitrile (455) was synthesized from 2-(3,5-bis(trifluoromethyl)phenyl)acetonitrile (454) and 1,4-dibromobutane following the procedure described for 1-(4-trifluoromethyl-phenyl)-cyclopentanecarbonitrile (237).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09045486B2
Source datasetuspto-grants-2015_06
ORD IDord-45278e337cb4481b8345cd07f9330637
Source noteuspto-grants-2015_06