1-[3,5-Bis(trifluoromethyl)phenyl]cyclopentanecarbonitrile → 1-(3,5-Bis(trifluoromethyl)phenyl)cyclopentanecarbaldehyde

HRID 2169485Notes

Reaction equation

HRID 2169485 reaction equation
[F:1][C:2]([F:21])([F:20])[C:3]1[CH:4]=[C:5]([C:13]2([C:18]#N)[CH2:17][CH2:16][CH2:15][CH2:14]2)[CH:6]=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:8]=1.FC(F)(F)C1C=CC(C2(C=[O:36])CCCC2)=CC=1>>[F:1][C:2]([F:21])([F:20])[C:3]1[CH:4]=[C:5]([C:13]2([CH:18]=[O:36])[CH2:17][CH2:16][CH2:15][CH2:14]2)[CH:6]=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:8]=1

Participants

3

Reactant 2

HCID 102671981-[3,5-Bis(trifluoromethyl)phenyl]cyclopentanecarbonitrileHCID 218996431-(4-Trifluoromethyl-phenyl)-cyclopentanecarbaldehyde

Product 1

HCID 867261091-(3,5-Bis(trifluoromethyl)phenyl)cyclopentanecarbaldehyde

Procedure

1-(3,5-bis(trifluoromethyl)phenyl)cyclopentanecarbaldehyde (456) was synthesized as a colourless liquid from 1-(3,5-bis(trifluoromethyl)phenyl)cyclopentanecarbonitrile (455) following the procedure described for 1-(4-trifluoromethyl-phenyl)-cyclopentanecarbaldehyde (238).

Sources & evidence

ORD record
ord-2a8cab4be8d94141a4c9b489cf2b80d3
Source dataset
uspto-grants-2015_06
Patent number
US09045486B2

Reaction notes

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